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A recent study conducted by American researchers suggests that some species present on the oral microbiota are associated with higher risk of pancreatic cancer.
Published in Gut journal, the study included 361 incident adenocarcinoma of pancreas and 371 matched controls from two prospective cohort studies. From pre-diagnostic oral wash samples, the authors characterized the composition of the oral microbiota using bacterial 16S ribosomal RNA (16S rRNA) gene sequencing. The associations between oral microbiota and risk of pancreatic cancer, controlling for the random effect of cohorts and other covariates, were examined using traditional and L1-penalised least absolute shrinkage and selection operator logistic regression.
The results showed that the presence of oral pathogens Porphyromonas gingivalis and Aggregatibacter actinomycetemcomitans was associated with higher risk of pancreatic cancer, but, carrying Phylum Fusobacteria and its genus Leptotrichia was associated with a decreased risk of developing that disease.
Fan X, Alekseyenko AV, Wu J, Peters BA, Jacobs EJ, Gapstur SM, et al. Human oral microbiome and prospective risk for pancreatic cancer: a population-based nested case-control study. Gut. 2016,